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Talk- Dillion Fox

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Structural Modeling of the Intrinsically Disordered Reflectin Protein

What
  • cmb seminar
When Jun 11, 2018
from 11:00 AM to 12:30 PM
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Cephalopods have the remarkable ability to manipulate incident light to camouflage with their environment. This unique capability is made possible by iridescent cells composed of over 90% reflectin protein. Recent studies have suggested that the reflectin protein interacts with cell membranes, which could drive the self-assembly of the optical devices that manipulate light.  We are attempting to predict the structure of the intrinsically disordered, highly conserved reflectin motif using two methods: ab initio structure prediction coupled with co-evolutionary data, and monte carlo folding simulations of randomly generated conformations. Both methods produce conformations which are compact but not uniquely folded, consistent with experimental data. We will use these structures as starting points to derive the structure of the motif bound to a membrane.

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