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Talk-Guest Speakar- Heloisa Nunes Bardallo

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What
  • cmb seminar
When Sep 25, 2017
from 11:00 AM to 12:30 PM
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Microscopic view of hydrogen motion from neutron scattering

 

 

 

Neutron science is the science of everyday life, providing a microscopic view of the materials we rely on daily. Neutrons, similarly to X-rays, penetrate matter. However, unlike X-rays, neutrons interact with matter in a different manner, thus allowing the identification of elements with very low molecular weight, including hydrogen. While X-rays allow the characterization of the microstructure of materials, neutron imaging provides information on proton distribution within this structure. For this reason, both X-rays and neutron imaging, complemented by neutron spectroscopy, which brings information about hydrogen mobility, can contribute for better understanding of complex structures.

 

In this talk I will discuss on this promising approach by presenting a couple of specific examples. The first is related to the investigation of the highly intricate pore structure of dental cements [1] and the second to a recent study of the encapsulation of the HBsAg protein, used in the Hepatitis B vaccine, into the SBA-15 adjuvant.[2] Finally I will give a brief overview in how solid-state techniques can in general be used in studying encapsulation process and release of drugs.[3],[4],[5]

 



[1] A.R. Benetti, J. Jacobsen, B. Lehnhoff, N.C.R. Momsen, D.V. Okhrimenko, M.T.F. Telling, N.Kardjilov, M. Strobl, T. Seydel, I. Manke and H.N. Bordallo (2015) How mobile are protons in the structure of dental glass ionomer cements? Sci. Rep. 5, 8972 (8 pages)

[2] Martin Kjærulf Rasmussen, BSc & MSc thesis- University of Copenhagen 2015 & 2017.

[3] M.L. Martins, R. Ignazzi, J. Eckert, B. Watts, R. Kaneno, W. F. Zambuzzi, L. Daemen, M. J. Saeki and H.N. Bordallo (2016) Restricted mobility of specific functional groups reduces anti- cancer drug activity in healthy cells. Sci. Rep. 6, 22478; doi: 10.1038/srep22478.

[4] E. C. dos Santos, Z. Rozynek, E. L. Hansen, R. Hartmann-Petersen, R. N. Klitgaard, A. Løbner-Olesen, L. Michels, A. Mikkelsen, T. S. Plivelic, H. N. Bordallo and J. O. Fossum (2017) Ciprofloxacin intercalated in fluorohectorite clay: Identical pure drug activity and toxicity with higher adsorption and controlled release rate. RSC Adv. 7, 26537–45

[5] M. L. Martins, J. Eckert, H. Jacobsen, E. C. dos Santos, R. Ignazzi, D. R. de Araujo, M.-C. Bellissent-Funel, F. Natali, M. M. Koza, A. Matic, E.de Paula and H. N. Bordallo (2017) Probing the dynamics of complexed local anesthetics via neutron scattering spectroscopy and DFT calculations. Int. J. Pharm. 524, 397–406.

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