Education:
- 09/1997-01/2003. Ph.D. in Physical Chemistry: Tsinghua University, Beijing, China. Advisor: Prof. Guo-Shi Wu.
- 09/1993-07/1997. B.S. in Chemistry: Tsinghua University, Beijing, China.
Biography:
Publications
1 H.B. Guo, A. Gorin, H. Guo. A Peptide-Linkage Deletion Procedure for Estimate of Energetic Contributions of Individual Peptide Groups in a Complex Environment: Application to Parallel β-Sheets. Interdisciplinary Sciences: Computational Life Sciences 2009, 1, 12-20.
2 H.B. Guo, H. Guo. Histone methylation catalyzed by protein lysine methyltransferase SET7/9 and origin of product specificity. Proceedings of the National Academy of Sciences of the United States of America. 2007, 104, 8797-8802.
3 Q. Xu, H.B. Guo, A. Gorin, H. Guo. Stabilization of a transition-state analogue at the active site of yeast cytosine deaminase: Importance of proton transfers. Journal of Physical Chemistry B 2007, 111, 6501-6506.
4 Q. Xu#, H.B. Guo#, A. Wlodawer, T. Nakayama, H. Guo. The QM/MM molecular dynamics and free energy simulations of the acylation reaction catalyzed by the serine carboxyl peptidase kumamolisin-As. Biochemistry 2007, 46, 3784-3792. # Co-first authors.
5 H.B. Guo, A. Wlodawer, T. Nakayama, Q. Xu, H. Guo. Catalytic role of proton transfers in the formation of a tetrahedral adduct in a serine carboxyl peptidase. Biochemistry 2006, 45, 9129-9137.
6 Q. Xu, H.B. Guo, A. Wlodawer, H. Guo. The importance of dynamics in substrate-assisted catalysis and specificity. Journal of the American Chemical Society 2006, 128, 5994-5995.
7 H.B. Guo, A. Wlodawer, H. Guo. A general acid-base mechanism for the stabilization of a tetrahedral adduct in a serine-carboxyl peptidase: A computational study. Journal of the American Chemical Society 2005, 127, 15662-15663.
8 H.B. Guo, N. Rao, Q. Xu, H. Guo. Origin of tight binding of a near-perfect transition-state analog by cytidine deaminase: Implications for enzyme catalysis. Journal of the American Chemical Society 2005, 127, 3191-3197.
9 H.B. Guo, R. F. Beahm, H. Guo. Stabilization and destabilization of the C–H…O=C hydrogen bonds involving proline residues in helices. Journal of Physical Chemistry B 2004, 108, 18065-18072.
10 H. Guo, H.B. Guo. Biological basis related to protein structures. In Computational Methods for Protein Structure Prediction and Modeling, Vol. 2: Structure Prediction. Y. Xu, D. Xu, J. Liang (Eds.). Springer: New York, 2007, 229-239.
