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Willy Evangelista Falcón
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Willy Evangelista Falcón

Graduate Research Assistant

UT-ORNL

Deparment of Biochemistry,Cell & Molecular Biology


Work: (865) 241-0896

Education:

  1. B.S Physics. Universidad Nacional de Ingeniería. Perú.

Biography:

After doing research on tuberculosis at the Universidad Peruana Cayetano Heredia in Perú and on protein-protein interactions at the University of Texas Medical Branch at Galveston, I decided to pursue my PhD at The University of Tennessee at Knoxville.  

Currently, I work with Jerome Baudry and Jeremy Smith on ensemble-based docking of small molecules to G-Protein Coupled Receptors (GPCRs). The goal of our work is to characterize the statistical and biophysical aspects of protein-drug interactions.

 

 Publications:

 

Evangelista W, Weir RL, Ellingson SR, Harris JB, Kapoor K, Smith JC, and Baudry J (2016).
Ensemble-based docking: From hit discovery to metabolism and toxicity predictions.
Bioorg. Med. Chem., 24(20):4928–4935.

Lindsay RJ, Johnson QR, Evangelista W, Nellas RB, and Shen T (2016).
DMSO enhanced conformational switch of an interfacial enzyme.
Biopolymers, 105(12):864–872.

Evangelista W, Yeh LC, Gmyrek A, Lee JC, and Lee JC (2015).
Long-Range Communication Network in the Type 1B Bone Morphogenetic Protein Receptor.
Biochemistry, 54(48):7079–7088.

Sheen P, Ferrer P, Gilman RH, Christiansen G, Moreno-Roman P, Gutierrez AH, Sotelo J, Evangelista W, Fuentes P, Rueda D, Flores M, Olivera P, Solis J, Pesaresi A, Lamba D, and Zimic M (2012).
Role of metal ions on the activity of Mycobacterium tuberculosis pyrazinamidase.
Am. J. Trop. Med. Hyg., 87(1):153–161.

Yeh LC, Falcon WE, Garces A, Lee JC, and Lee JC (2012).
A host-guest relationship in bone morphogenetic protein receptor-II defines specificity in ligand-receptor recognition.
Biochemistry, 51(35):6968–6980.

Quiliano M, Gutierrez AH, Gilman RH, Lopez C, Evangelista W, Sotelo J, Sheen P, and Zimic M (2011).
Structure-Activity relationship in mutated pyrazinamidases from Mycobacterium tuberculosis.
Bioinformation, 6(9):335–339.

Zimic M, Gutierrez AH, Gilman RH, Lopez C, Quiliano M, Evangelista W, Gonzales A, Garcia HH, and Sheen P (2011).
Immunoinformatics prediction of linear epitopes from Taenia solium TSOL18.
Bioinformation, 6(7):271–274.

Bernabe-Ortiz A, Curioso WH, Gonzales MA, Evangelista W, Castagnetto JM, Carcamo CP, Hughes JP, Garcia PJ, Garnett GP, and Holmes KK (2008).
Handheld computers for self-administered sensitive data collection: a comparative study in Peru.
BMC Med Inform Decis Mak, 8:11.