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Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
Work: 865.574.5896

Address:
E362, Bldg.2040
1 Bethel Valley Rd.
Oak Ridge, TN 37831-6309

Websites

 

Google Scholar: https://scholar.google.com/citations?user=N_dZXxgAAAAJ&hl=en&oi=ao

 

Education / Biography

 

Ph.D. in Chemical Engineering, University of Tennessee, Knoxville, 2012-2017

B.S. in Chemical Engineering, Marathwada University, India

 

Research Interests

 

  • Development of a broadly protective vaccine against Group A Strep


  • Functional Nanomaterials

Titanium Dioxide nanoparticle interaction with lipid bilayers 

                              

 

                                Illustration of Bilayer - Nanoparticle simulation system                                         Effect on bilayer order parameters                

TiOis a transition metal oxide and finds applications in pigments, additives, catalysts and construction materials. However, some experimental studies have uncovered the potential cytotoxic effects of transition metal oxide nanoparticles which include changes in cell morphology, mitochondrial functions, membrane leakage, necrosis and apoptosis. With their extensive use in a wide array of applications it has become of vital importance to understand their potential cytotoxic effect to design them for safe applications. Molecular dynamics (MD) simulations can help shed some light on the nature of the interaction when the metal oxide nanoparticle first encounters the cell membrane. Through atomistic MD study, we assess the effect of the TiO2 nanoparticle on the structural, mechanical and dynamical properties of neutral DOPC and charged DOPG bilayers. These preliminary studies pave the way for a more detailed study into the differential interactions of various other metal oxide nanoparticles with mixed lipid bilayers.

 

  • Peptide - MHC binding prediction for cancer vaccine development


  • Ion transport through nanopores

Publications

1. Aranha, M.P. and B.J. Edwards, Ion transport through single-walled carbon nanotubes: Effects of electric field and fixed surface charge. Chemical Physics Letters, 2018. [PDF]

 

 

 
 
 

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