Education

PhD in Physics, Wayne State University, USA, 2017

M.S. in Physics, Tribhuvan University, Nepal, 2011

B.S. in Physics, Tribhuvan University, Nepal, 2008

Research Interests

I am interested in modeling the structure of flexible proteins that include intrinsically disordered proteins and multi-domain complex connected by flexible linkers. Currently, I am working on modeling the ensemble of structures of such flexible proteins implementing synergistic approach of combining small-angle (X-ray/neutron) scattering (SAXS/SANS) and all-atom molecular dynamics simulations using enhanced sampling method. In addition, I am also working on understanding the plant cell wall structure and interactions using SANS and MD simulation. Earlier, during my Ph.D., I have worked on investigation of dynamics-function relationship in proteins using different scattering techniques such as quasi-elastic neutron scattering and inelastic neutron/X-ray scattering.

Publications 

• U. R. Shrestha, D. Bhowmik, J. R. D. Copley, M. Tyagi, J. B. Leao, X.-Q. Chu. Effects of pressure on the dynamics of an oligomeric protein from deep-sea hyperthermophile. Proc. Natl. Acad. Sci. U. S. A., 112(45): 13886-13891 (2015)
• U. R. Shrestha, S. M. D. C. Perera, D. Bhowmik, U. Chawla, E. Mamontov, M. F. Brown, X.-Q. Chu. Quasi-elastic neutron scattering reveals ligand-induced protein dynamics of a G-protein-coupled receptor. J. Phys. Chem. Lett., 7: 4130-4136 (2016)
• U. R. Shrestha, D. Bhowmik, K. W. Van Delinder, E. Mamontov, H. O’Neill, Q. Zhang, A. Alatas, X.-Q. Chu. Collective excitations in protein as a measure of balance between its softness and rigidity. J. Phys. Chem. B, 121(5): 923-930 (2017)
• I. Dhiman, D. Bhowmik, U. R. Shrestha, D. R. Cole, S. Gautam. Effect of molecular shape on rotation under severe confinement. Chem. Eng. Sci., 180, 33-41 (2018)
• I. Dhiman, U. R. Shrestha, D. Bhowmik, D. R. Cole, S. Gautam. Influence of molecular shape on self-diffusion under severe confinement: A molecular dynamics study. Chem. Phys., 516, 92-102 (2018)

           Google Scholar link: https://scholar.google.com/citations?user=pNXPjo8AAAAJ&hl=en